Fulbright, R. et al (2014) Glutamate and Choline Levels Predict Individual Differences in Reading Ability in Emergent Readers, The Journal of Neuroscience, 12 March 2014, 34(11): 4082-4089.
The research team measured levels of glutamate, choline, and other metabolites in 75 children, aged 6 to 10, whose reading abilities ranged from what is considered impaired to superior. The researchers conducted behavioral testing to characterize the children’s reading, language, and general cognitive skills, and used MR spectroscopy to assess metabolite levels. They found that children with higher glutamate and choline levels in their brains tended to have lower composite scores for reading and language. In follow-up testing two years later, the same correlation still existed for initial glutamate levels. This study is believed to be the first to examine neurochemistry in a longitudinal study of children during the critical period when they are considered "emergent readers" — the age at which neurocircuits that support skilled reading and speaking are still developing.